Effects of idebenone
on electroencephalograms of patients with cerebrovascular disorders.
Nakano T, Miyasaka M, Mori K, Ohtaka T, Kifune Y.
Department of Psychiatry,
Dokkyo University School of Medicine, Tochigi,
Arch Gerontol Geriatr 1989 May;8(3):355-66
A daily dose of 90 mg of idebenone
was given to nine patients with cerebrovascular disorders to investigate its
effects on clinical symptoms and electroencephalograms (EEG). Changes in EEG
before and after the administration were compared quantitatively by computer
analysis using the wave-form recognition method. Significant increase in
frequency in the alpha band (O1) and trends of increased appearance of beta
waves, decreased appearance of alpha 1 bands, and lowered amplitude in the
alpha 1 and alpha 2 bands were observed after administration of idebenone. The
theta waves of 30 microV and over had a significantly diminished maximum
amplitude (C3) and a tendency to appear less often. Mean frequency of the EEG
and appearance of fast waves apparently increased in the patients showing
improvement of the clinical symptoms as compared with those not showing
improvement. The results suggested that idebenone improved the EEG in the
patients with cerebrovascular disorders, causing changes in EEG similar to
those observed with psychostimulants.