Idebenone: interaction with respiratory complexes of heart mitochondria

The interaction of Q analogs, particularly hydroxydecyl benzoquinone (idebenone), with the respiratory complexes of heart mitochondria.

Esposti MD, Ngo A, Ghelli A, Benelli B,
Carelli V, McLennan H, Linnane AW.

Centre for Molecular Biology and Medicine,
Monash University, Melbourne, Victoria, Australia.
Arch Biochem Biophys 1996 Jun 15;330(2):395-400

ABSTRACT

We have studied the interaction of idebenone (2,3-dimethoxy-5-methy-6-(10-hydroxy)decyl-1,4-benzoquinone) with the energy-conserving complexes of the respiratory chain in beef heart mitochondria and compared its energetic efficiency with that of other analogs of coenzyme Q. Idebenone is a very effective substrate for succinate:Q reductase and ubiquinol:cytochrome c reductase, but it is clearly a poor substrate for NADH:Q reductase (complex I). Indeed, idebenone is a strong inhibitor of both the redox and proton pumping activity of complex I, showing effects in part similar to those of coenzyme Q-2. However, the mechanism of idebenone interaction with complex I may be different from that of Q-2 because of its different sensitivity to inhibitors. The possible relevance of the present findings to the therapeutic use of idebenone is discussed.

Idebenone - the ultimate anti-aging drug. (article)

Alzheimer's disease
Idebenone  in the treatment of Alzheimer's disease
Idebenone efficacy of idebenone in the treatment of Alzheimer's disease
Idebenone Nerve Growth Factor synthesis stimulators in Alzheimer's disease
Idebenone in the treatment of dementia of the Alzheimer type
Idebenone cognitive enhancement therapy for Alzheimer's disease

MELAS
Idebenone improves cerebral mitochondrial oxidative metabolism in MELAS
Idebenone in young patients with mitochondrial encephalomyopathy (MELAS)
Idebenone therapy in Mitochondrial encephalomyopathy (MELAS)
Idebenone and Mitochondrial encephalomyopathy (MELAS)
Idebenone successful therapy with idebenone in Mitochondrial encephalomyopathy (MELAS)
.
Cardiomyopathy
Idebenone improvement in mitochondrial cardiomyopathy following treatment with idebenone
Idebenone   effect of idebenone on cardiomyopathy in Friedreich's ataxia
.
Leber hereditary optic neuropathy (LHON)
Idebenone does it shorten the time to visual recovery in Leber hereditary optic neuropathy?
Idebenone improvement in a patient with Leber's hereditary optic neuropathy (LHON)

Misc.
Idebenone use in age-related cognitive disorders

Idebenone protects hippocampal neurons against beta amyloid neurotoxicity

Idebenone functions as a potent protective hepatocyte antioxidant

Idebenone neuroprotective effects of idebenone can be attributed to its antioxidant ability

Idebenone inhibition of brain mitochondrial swelling

Idebenone suppression of cold ischemia/reperfusion injury of liver endothelium

Idebenone ability to eliminate a nitroxide radical in the rat

Idebenone interaction with respiratory complexes of heart mitochondria

Idebenone effect on serotonin release and seroton receptors in rats

Idebenone protects hepatic microsomes against damage in organ preservation solutions

Idebenone protects against toxicity induced by low density lipoprotein

Idebenone protects against disorders due to cerebral hypoxia or ischemia

Idebenone protects against toxicity induced by low density lipoprotein

Idebenone attenuates neuronal degeneration induced by excitotoxins

Idebenone augments long-term potentiation in hippocampal slices in the guinea pig

Idebenoneeffects on lipid peroxidation in erythrocytes of stroke-prone, hypertensive rats

Idebenone brain distribution and its effect on local cerebral glucose utilization in rats

Idebenone effects on acetylcholine levels in the brains of rats with cerebral ischemia

Idebenone protective effect of idebenone against hypoxia in mice

Idebenone improves learning and memory impairment induced in rats

Idebenone effects of idebenone on neurological deficits in stroke-prone rats

Idebenone effects on memory induced impairment in rats

Idebenone effects of idebenone on cerebral blood flow in rats with cerebral ischemia

Idebenone inhibition of brain mitochondrial swelling by idebenone

Idebenone inhibition of platelet aggregation by idebenone

Idebenone effects of idebenone on monoamine metabolites of patients with dementia

Idebenone effects of idebenone on metabolism of monoamines and cyclic AMP formation

Idebenone effects on impairment of radial maze learning in cerebral embolized rats

Idebenone effect of idebenone on lipid peroxidation in rat brain homogenate

Idebenone effects on muricidal behavior in rats with raphe lesions

Idebenone inhibitory effect of idebenone on vascular lesions in hypertensive rats

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