|
Effect of idebenone and
various nootropic drugs on lipid peroxidation in rat brain homogenate in the
presence of succinate.
[Article in Japanese]
Suno M, Nagaoka A.
Central Research Division,
Takeda Chemical Industries, Ltd., Osaka, Japan.
Nippon Yakurigaku Zasshi 1988 May;91(5):295-9
ABSTRACT
The effects of
idebenone and various nootropic drugs on lipid peroxidation in rat brain
homogenate were examined. Idebenone inhibited lipoperoxide (LPO) production in
brain homogenate in a concentration-dependent manner, with an IC50 of 38 microM.
The inhibition was strongly enhanced (about 100-fold) by adding succinate, a
substrate in the mitochondrial respiration. The optimal concentration of
succinate was 0.5 mM. Inhibition of lipid peroxidation in brain homogenate by
various nootropic drugs in the presence or absence of succinate was then
examined. Drugs added to the brain homogenate at 100 microM in the absence of
succinate inhibited LPO production in the order: idebenone greater than
vinpocetine greater than bifemelane greater than indeloxazine greater than
calcium hopantenate. However, when the drugs were added at 1 microM in the
presence of succinate, only idebenone demonstrated inhibition. These
results suggest that although almost all of the drugs tested inhibit lipid
peroxidation in brain homogenate, only idebenone is activated by succinate, the
other drugs being insensitive to this compound.
- Idebenone
- the ultimate anti-aging drug. (article)
Alzheimer's disease
Idebenone in
the treatment of Alzheimer's disease
Idebenone
efficacy of idebenone in the treatment of Alzheimer's
disease
Idebenone
Nerve Growth Factor synthesis stimulators in Alzheimer's
disease
Idebenone
in the treatment of dementia of the Alzheimer
type
Idebenone
cognitive enhancement therapy for Alzheimer's
disease
Friedreich's ataxia.
Idebenone and reduced cardiac hypertrophy in Friedreich's ataxia.
Idebenone
causes improvement in mitochondrial
cardiomyopathy
Idebenone
cerebellar improvement in Friedreich's ataxia after 3 months
Idebenone effect
of idebenone on cardiomyopathy in Friedreich's ataxia
Idebenone
Friedreich's ataxia and frataxin
Idebenone Frataxin: Its
role in iron metabolism and Friedreich's Ataxia
Idebenone mitochondrial dysfunction in Friedreich's ataxia
Idebenone helps
heart function
in Friedreich's ataxia
MELAS
Idebenone
improves cerebral mitochondrial oxidative metabolism in MELAS
Idebenone
in young patients with mitochondrial encephalomyopathy (MELAS)
Idebenone
therapy in Mitochondrial encephalomyopathy (MELAS)
Idebenone
and Mitochondrial encephalomyopathy (MELAS)
Idebenone
successful therapy with idebenone in Mitochondrial
encephalomyopathy (MELAS)
.
Cardiomyopathy
Idebenone
improvement in mitochondrial cardiomyopathy
following treatment with idebenone
Idebenone
effect of idebenone on
cardiomyopathy in Friedreich's ataxia
.
Leber hereditary optic neuropathy (LHON)
Idebenone
does it shorten the time to visual recovery in Leber hereditary optic
neuropathy?
Idebenone
improvement in a patient with Leber's hereditary optic neuropathy (LHON)
Misc.
Idebenone
use in age-related cognitive disorders
Idebenone
protects hippocampal neurons against beta amyloid neurotoxicity
Idebenone
functions as a potent protective
hepatocyte antioxidant
Idebenone
neuroprotective effects
of idebenone can be attributed to its antioxidant ability
Idebenone
inhibition of brain
mitochondrial swelling
Idebenone
suppression of cold ischemia/reperfusion
injury of liver endothelium
Idebenone
ability to eliminate a nitroxide
radical in the rat
Idebenone
interaction with respiratory complexes of heart
mitochondria
Idebenone
effect on serotonin release and seroton receptors in
rats
Idebenone
protects hepatic microsomes against damage in organ preservation solutions
Idebenone
protects against
toxicity induced by low density lipoprotein
Idebenone
protects against disorders due to cerebral hypoxia
or ischemia
Idebenone
protects against toxicity induced by low density
lipoprotein
Idebenone
attenuates neuronal degeneration induced by
excitotoxins
Idebenone
augments long-term potentiation in
hippocampal slices in the guinea pig
Idebenoneeffects
on lipid
peroxidation in erythrocytes of stroke-prone, hypertensive rats
Idebenone
brain distribution and its effect on local cerebral
glucose utilization in rats
Idebenone
effects
on acetylcholine
levels in the brains of rats with cerebral ischemia
Idebenone
protective effect of idebenone against hypoxia in
mice
Idebenone
improves learning and memory impairment induced in
rats
Idebenone
effects
of idebenone on
neurological deficits in stroke-prone rats
Idebenone
effects
on memory induced impairment in rats
Idebenone
effects of idebenone on cerebral blood flow in rats with cerebral ischemia
Idebenone
inhibition
of brain mitochondrial swelling by idebenone
Idebenone
inhibition of platelet
aggregation by idebenone
Idebenone
effects of idebenone on monoamine metabolites of
patients with dementia
Idebenone
effects of idebenone on
metabolism of monoamines and cyclic AMP formation
Idebenone effects
on impairment of radial maze learning in cerebral embolized rats
Idebenone
effect of idebenone on lipid peroxidation in
rat brain homogenate
Idebenone
effects on muricidal behavior in rats with
raphe lesions
Idebenone
inhibitory effect of idebenone on vascular lesions in
hypertensive rats
Vinpocetine | Galantamine | CDP Choline |
Picamilon
Pyritinol | Modafinil | Deprenyl | Piracetam
Home | Order
|
