Effects of idebenone on memory impairment induced in ischemic and embolization models of cerebrovascular disturbance in rats.

Yamazaki N, Kiyota Y, Take Y, Miyamoto M, Nagawa Y, Nagaoka A.

Central Research Division, 
Takeda Chemical Industries, Ltd., Osaka, Japan.
Arch Gerontol Geriatr 1989 May;8(3):213-24

ABSTRACT

Two rat models of memory impairment in passive avoidance learning induced by cerebrovascular disturbance, were established to estimate the effects of a cerebral metabolic enhancer, idebenone. Transient and global cerebral ischemia in rats, produced by 4-vessel occlusion for 200 s immediately after the acquisition trial of passive avoidance learning, shortened the latencies in the retention test trial performed 24 h later. This retrograde amnesia was reversed significantly by idebenone administered orally or intraperitoneally at the doses of 10 and 30 mg/kg before the retention test trial. Idebenone at a dose of 10 mg/kg, given intraperitoneally before or immediately after the ischemia, also markedly inhibited the appearance of amnesia. In the second model, permanent and cerebral hemisphere embolization produced by injecting 2,000 microspheres into the internal carotid artery, significantly impaired passive avoidance learning performed 7 days later. The repeated administration of idebenone (30 mg/kg, i.p.). once a day after the embolization, significantly improved the impairment of passive avoidance learning in the embolized rats. Furthermore, physostigmine and arginine-vasopressin as reference compounds improved the impairment of passive avoidance learning in these models. These findings suggest that idebenone ameliorates memory impairment induced by cerebral vascular disturbance in rats.

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Idebenone - the ultimate anti-aging drug.  (article)
  
Alzheimer's disease
Idebenone  in the treatment of Alzheimer's disease
Idebenone  efficacy of idebenone in the treatment of Alzheimer's disease
Idebenone  Nerve Growth Factor synthesis stimulators in Alzheimer's disease
Idebenone  in the treatment of dementia of the Alzheimer type
Idebenone  cognitive enhancement therapy for Alzheimer's disease

Friedreich's ataxia.
Idebenone  and reduced cardiac hypertrophy in Friedreich's ataxia.
Idebenone  causes improvement in mitochondrial cardiomyopathy
Idebenone  cerebellar improvement in Friedreich's ataxia after 3 months
Idebenone   effect of idebenone on cardiomyopathy in Friedreich's ataxia
Idebenone  Friedreich's ataxia and frataxin
Idebenone   Frataxin: Its role in iron metabolism and Friedreich's Ataxia
Idebenone   mitochondrial dysfunction in Friedreich's ataxia
Idebenone   helps heart function in Friedreich's ataxia

MELAS
Idebenone  improves cerebral mitochondrial oxidative metabolism in MELAS
Idebenone  in young patients with mitochondrial encephalomyopathy (MELAS)
Idebenone  therapy in Mitochondrial encephalomyopathy (MELAS)
Idebenone  and Mitochondrial encephalomyopathy (MELAS)
Idebenone  successful therapy with idebenone in Mitochondrial encephalomyopathy (MELAS)
 .
Cardiomyopathy
Idebenone  improvement in mitochondrial cardiomyopathy following treatment with idebenone
Idebenone   effect of idebenone on cardiomyopathy in Friedreich's ataxia
 .
Leber hereditary optic neuropathy (LHON)
Idebenone  does it shorten the time to visual recovery in Leber hereditary optic neuropathy?
Idebenone  improvement in a patient with Leber's hereditary optic neuropathy (LHON)

Misc.
Idebenone  use in age-related cognitive disorders

Idebenone  protects hippocampal neurons against beta amyloid neurotoxicity

Idebenone  functions as a potent protective hepatocyte antioxidant

Idebenone  neuroprotective effects of idebenone can be attributed to its antioxidant ability

Idebenone  inhibition of brain mitochondrial swelling

Idebenone  suppression of cold ischemia/reperfusion injury of liver endothelium

Idebenone  ability to eliminate a nitroxide radical in the rat

Idebenone  interaction with respiratory complexes of heart mitochondria

Idebenone  effect on serotonin release and seroton receptors in rats

Idebenone  protects hepatic microsomes against damage in organ preservation solutions

Idebenone  protects against toxicity induced by low density lipoprotein

Idebenone  protects against disorders due to cerebral hypoxia or ischemia

Idebenone  protects against toxicity induced by low density lipoprotein

Idebenone  attenuates neuronal degeneration induced by excitotoxins

Idebenone  augments long-term potentiation in hippocampal slices in the guinea pig

Idebenoneeffects on lipid peroxidation in erythrocytes of stroke-prone, hypertensive rats

Idebenone  brain distribution and its effect on local cerebral glucose utilization in rats

Idebenone  effects on acetylcholine levels in the brains of rats with cerebral ischemia

Idebenone  protective effect of idebenone against hypoxia in mice

Idebenone  improves learning and memory impairment induced in rats

Idebenone  effects of idebenone on neurological deficits in stroke-prone rats

Idebenone  effects on memory induced impairment in rats

Idebenone  effects of idebenone on cerebral blood flow in rats with cerebral ischemia

Idebenone  inhibition of brain mitochondrial swelling by idebenone

Idebenone  inhibition of platelet aggregation by idebenone

Idebenone  effects of idebenone on monoamine metabolites of patients with dementia

Idebenone  effects of idebenone on metabolism of monoamines and cyclic AMP formation

Idebenone  effects on impairment of radial maze learning in cerebral embolized rats

Idebenone  effect of idebenone on lipid peroxidation in rat brain homogenate

Idebenone  effects on muricidal behavior in rats with raphe lesions

Idebenone  inhibitory effect of idebenone on vascular lesions in hypertensive rats

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