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Effects of idebenone on the
levels of acetylcholine,
choline, free fatty acids, and energy metabolites
in
the brains of rats with cerebral ischemia.
Kakihana M, Yamazaki N, Nagaoka A.
Central Research Division,
Takeda Chemical Industries, Ltd., Osaka, Japan.
Arch Gerontol Geriatr 1989 May;8(3):247-56
ABSTRACT
Cerebral ischemia was induced by a
200-s occlusion of both common carotid arteries in rats in which both
vertebral arteries had been permanently cauterized. In the ischemic rats, a
significant decrease in acetylcholine (ACh) and a marked increase in choline
were observed in the cerebral cortex, hippocampus, striatum, and diencephalon.
A slight increase in choline was also observed in the cerebellum and brain
stem. Pretreatment with idebenone (10 mg/kg, i.p.) inhibited the decrease in
ACh and the increase in choline in the forebrain regions. In addition, the
same dose of idebenone inhibited the increments of lactate and free fatty acid
contents and tended to inhibit the decrement of the ATP content in the
cerebral cortex of the cerebral ischemic rats. These results indicate that idebenone
inhibits the alteration of the ACh level and the disruption of
membrane phospholipids in the brain of ischemic rats; these effects may be
mediated by improved cerebral energy metabolism.
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functions as a potent protective
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of idebenone can be attributed to its antioxidant ability
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protects against
toxicity induced by low density lipoprotein
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protects against disorders due to cerebral hypoxia
or ischemia
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protects against toxicity induced by low density
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attenuates neuronal degeneration induced by
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on memory induced impairment in rats
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of brain mitochondrial swelling by idebenone
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aggregation by idebenone
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