Biochemical and
histochemical studies of the effects of cerebral metabolism-improving drugs on
NADPH diaphorase activity in mouse brain.
Tsuruo Y, Ishimura K, Tamura M, Kagawa S, Morita K.
Department of Anatomy,
Tokushima University School of Medicine, Japan.
Jpn J Pharmacol 1994 Jul;65(3):285-8
ABSTRACT
The effects of cerebral
metabolism-improving drugs on NADPH diaphorase activity in the mouse brain
were studied, and we found that diaphorase activity in the post-mitochondrial
fraction of brain homogenate was enhanced by idebenone in a
concentration-dependent manner. Histochemical studies also indicated that
diaphorase staining was intensified by idebenone at the same concentration.
These results suggest that idebenone may stimulate the production of nitric
oxide, probably through its direct action on nitric oxide synthase, thus
producing its protective action on neurological disorders due to cerebral
hypoxia or ischemia as a consequence of dilating the cerebral blood vessels.
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efficacy of idebenone in the treatment of Alzheimer's
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Nerve Growth Factor synthesis stimulators in Alzheimer's
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in the treatment of dementia of the Alzheimer type
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MELAS
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improves cerebral mitochondrial oxidative metabolism in MELAS
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in young patients with mitochondrial encephalomyopathy (MELAS)
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therapy in Mitochondrial encephalomyopathy (MELAS)
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and Mitochondrial encephalomyopathy (MELAS)
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successful therapy with idebenone in Mitochondrial
encephalomyopathy (MELAS)
.
Cardiomyopathy
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improvement in mitochondrial cardiomyopathy following
treatment with idebenone
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effect of idebenone on
cardiomyopathy in Friedreich's ataxia
.
Leber hereditary optic neuropathy (LHON)
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does it shorten the time to visual recovery in Leber hereditary optic
neuropathy?
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improvement in a patient with Leber's hereditary optic neuropathy (LHON)
Misc.
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use in age-related cognitive disorders
Idebenone
protects hippocampal neurons against beta amyloid neurotoxicity
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functions as a potent protective
hepatocyte antioxidant
Idebenone
neuroprotective effects of
idebenone can be attributed to its antioxidant ability
Idebenone
inhibition of brain mitochondrial
swelling
Idebenone
suppression of cold ischemia/reperfusion
injury of liver endothelium
Idebenone
ability to eliminate a nitroxide
radical in the rat
Idebenone
interaction with respiratory complexes of heart
mitochondria
Idebenone
effect on serotonin release and seroton receptors in rats
Idebenone
protects hepatic microsomes against damage in organ preservation solutions
Idebenone
protects against toxicity
induced by low density lipoprotein
Idebenone
protects against disorders due to cerebral hypoxia or
ischemia
Idebenone
protects against toxicity induced by low density
lipoprotein
Idebenone
attenuates neuronal degeneration induced by excitotoxins
Idebenone
augments long-term potentiation in
hippocampal slices in the guinea pig
Idebenoneeffects
on lipid peroxidation
in erythrocytes of stroke-prone, hypertensive rats
Idebenone
brain distribution and its effect on local cerebral
glucose utilization in rats
Idebenone
effects
on acetylcholine levels
in the brains of rats with cerebral ischemia
Idebenone
protective effect of idebenone against hypoxia in mice
Idebenone
improves learning and memory impairment induced in rats
Idebenone
effects
of idebenone on
neurological deficits in stroke-prone rats
Idebenone
effects
on memory induced impairment in rats
Idebenone
effects of idebenone on cerebral blood flow in rats with cerebral ischemia
Idebenone
inhibition
of brain mitochondrial swelling by idebenone
Idebenone
inhibition of platelet aggregation by
idebenone
Idebenone
effects of idebenone on monoamine metabolites of patients
with dementia
Idebenone
effects of idebenone on
metabolism of monoamines and cyclic AMP formation
Idebenone effects
on impairment of radial maze learning in cerebral embolized rats
Idebenone
effect of idebenone on lipid peroxidation in rat
brain homogenate
Idebenone
effects on muricidal behavior in rats with raphe
lesions
Idebenone
inhibitory effect of idebenone on vascular lesions in
hypertensive rats
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