Idebenone: effect on serotonin release and serotonergic receptors in rats

Effect of idebenone on in vivo serotonin release and serotonergic receptors in young and aged rats.

Scavini C, Rozza A, Lanza E, Favalli L, Racagni G, Brunello N.

Institute of Pharmacology,
University of Pavia, Italy.
Eur Neuropsychopharmacol 1996 May;6(2):95-102

ABSTRACT

The effect of idebenone on the serotonergic system was evaluated in the aging rat by measuring the kinetic constants of 3H-5HT and 3H-ketanserin binding sites in the cerebral cortex of rats at 3, 15 and 24 months of age following acute and subchronic administration of the drug. Idebenone displayed no in vitro affinity toward any population of serotonin receptors and did not modify their kinetic parameters after a single dose of 100 mg/kg, at any age tested. A subchronic treatment with the drug for 21 days at the dose of 30 mg/kg did not induce any relevant change in 3- and 15-month-old rats, whereas it significantly increased the density of both 3H-5HT and 3H-ketanserin binding sites in 24-month-old rats, where a lower number of receptors is detected as a consequence of aging. This effect was rather specific, since under the same experimental conditions no changes were detected in the density of cortical beta-adrenergic receptors in aged animals. In microdialysis studies, acute administration with idebenone did not affect 5HT and 5HIAA release at any age. Conversely, the pattern of serotonin metabolism was significantly modified in aged rats following repeated treatment with idebenone and was partially restored to a value similar to the one observed in young animals. These results suggest that idebenone, a putative neuroprotective agent which has been shown to improve brain metabolism in ischemic conditions, might also attenuate age-associated neuronal damage, acting probably on several neurotransmitter systems which undergo selective modification during aging.

Idebenone - the ultimate anti-aging drug. (article)

Alzheimer's disease
Idebenone  in the treatment of Alzheimer's disease
Idebenone efficacy of idebenone in the treatment of Alzheimer's disease
Idebenone Nerve Growth Factor synthesis stimulators in Alzheimer's disease
Idebenone in the treatment of dementia of the Alzheimer type
Idebenone cognitive enhancement therapy for Alzheimer's disease

MELAS
Idebenone improves cerebral mitochondrial oxidative metabolism in MELAS
Idebenone in young patients with mitochondrial encephalomyopathy (MELAS)
Idebenone therapy in Mitochondrial encephalomyopathy (MELAS)
Idebenone and Mitochondrial encephalomyopathy (MELAS)
Idebenone successful therapy with idebenone in Mitochondrial encephalomyopathy (MELAS)
.
Cardiomyopathy
Idebenone improvement in mitochondrial cardiomyopathy following treatment with idebenone
Idebenone   effect of idebenone on cardiomyopathy in Friedreich's ataxia
.
Leber hereditary optic neuropathy (LHON)
Idebenone does it shorten the time to visual recovery in Leber hereditary optic neuropathy?
Idebenone improvement in a patient with Leber's hereditary optic neuropathy (LHON)

Misc.
Idebenone use in age-related cognitive disorders

Idebenone protects hippocampal neurons against beta amyloid neurotoxicity

Idebenone functions as a potent protective hepatocyte antioxidant

Idebenone neuroprotective effects of idebenone can be attributed to its antioxidant ability

Idebenone inhibition of brain mitochondrial swelling

Idebenone suppression of cold ischemia/reperfusion injury of liver endothelium

Idebenone ability to eliminate a nitroxide radical in the rat

Idebenone interaction with respiratory complexes of heart mitochondria

Idebenone effect on serotonin release and seroton receptors in rats

Idebenone protects hepatic microsomes against damage in organ preservation solutions

Idebenone protects against toxicity induced by low density lipoprotein

Idebenone protects against disorders due to cerebral hypoxia or ischemia

Idebenone protects against toxicity induced by low density lipoprotein

Idebenone attenuates neuronal degeneration induced by excitotoxins

Idebenone augments long-term potentiation in hippocampal slices in the guinea pig

Idebenoneeffects on lipid peroxidation in erythrocytes of stroke-prone, hypertensive rats

Idebenone brain distribution and its effect on local cerebral glucose utilization in rats

Idebenone effects on acetylcholine levels in the brains of rats with cerebral ischemia

Idebenone protective effect of idebenone against hypoxia in mice

Idebenone improves learning and memory impairment induced in rats

Idebenone effects of idebenone on neurological deficits in stroke-prone rats

Idebenone effects on memory induced impairment in rats

Idebenone effects of idebenone on cerebral blood flow in rats with cerebral ischemia

Idebenone inhibition of brain mitochondrial swelling by idebenone

Idebenone inhibition of platelet aggregation by idebenone

Idebenone effects of idebenone on monoamine metabolites of patients with dementia

Idebenone effects of idebenone on metabolism of monoamines and cyclic AMP formation

Idebenone effects on impairment of radial maze learning in cerebral embolized rats

Idebenone effect of idebenone on lipid peroxidation in rat brain homogenate

Idebenone effects on muricidal behavior in rats with raphe lesions

Idebenone inhibitory effect of idebenone on vascular lesions in hypertensive rats

Hit Counter